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Multipotential hematopoietic
stem cell
(Hemocytoblast)
Common myeloid progenitor
Megakaryocyte
Thrombocytes
Erythrocyte
Mast cell
Myeloblast
Basophil
Neutrophil
Eosinophil
Monocyte
Macrophage
Common lymphoid progenitor
Small lymphocyte
B lymphocyte
T lymphocyte
Plasma cell
Natural killer cell
(Large granular lymphocyte)
R-HSA-168256
T
H
2
T
H
1
NEUTROPHI
L
CELLULAR MEMBRANE
I
L
JAK1
JAK2
P
P
CY
T
OKINE SIGNALING
IN IMMUNE SYSTEM
XXX/YY
Y
DENDRITIC CEL
L
MACROPHAGE
PA
THOGEN
NK CEL
L
INN
A
TE IMMUNE SYSTEM
XXX/YY
Y
INFECTED CEL
L
ADAPTIVE IMMUNE SYSTEM
APC
PLASM
A
CEL
L
T
C
CD8
B CEL
L
CD19
T
H
O
CD4
IFN-
gamma
IL2
IL2
MEMO
R
Y
CEL
L
XXX/YY
Y
TNFSF9
CD28
B7
TCR
MHC II
TNFRSF9
CD40
L
CD40
MHC I
TCR
TCR
MHC II
CD40
L
CD40
CD28
B7
TLR
MHC I
CY
T
OKINE
RECEP
T
OR
MB
L
TCR
MHC II
Branch Color
1
50.5
100
Node Color
1
50.5
100
Node Size
0
100
AAK1
Abl
Arg
Ack
ACtR2
ACtR2B
ADCK1
ADCK2
ADCK3
ADCK4
ADCK5
Akt1/PKBα
Akt2/PKBβ
Akt3/PKBγ
ALK
ALK1
ALK2
ALK4
ALK7
AlphaK1
AlphaK2
AlphaK3
AMPKα1
AMPKα2
ANKRD3
ANPα
ANPβ
ARAF
ATM
ATR
AurA/Aur2
AurB/Aur1
AurC/Aur3
Axl
BARK1/GRK2
BARK2/GRK3
BCKDK
BIKE
BLK
BMPR1A
BMPR1B
BMPR2
Etk/BMX
BRAF
Brd2
Brd3
Brd4
BrdT
Brk
BRSK1
BRSK2
BTK
Bub1
BubR1
CaMK1α
CaMK1β
CaMK1δ
CaMK1γ
CaMK2α
CaMK2β
CaMK2δ
CaMK2γ
CaMK4
CAMKK1
CAMKK2
caMLCK
CASK
CCK4/PTK7
CCRK
CDC2/CDK1
CDC7
CDK10
CDK11
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CDK8
CDK9
CDKL1
CDKL2
CDKL3
CDKL4
CDKL5
Chak1
Chak2
CHED
CHK1
CHK2
CK1α
CK1α2
CK1δ
CK1ε
CK1γ1
CK1γ2
CK1γ3
CK2α1
CK2α2
CLIK1
CLIK1L
CLK1
CLK2
CLK3
CLK4
COT
CRIK
CRK7
CSK
CTK
CYGD
CYGF
DAPK1
DAPK2
DAPK3
DCAMKL1
DCAMKL2
DCAMKL3
DDR1
DDR2
DLK
DMPK
DMPK2
DNAPK
DRAK1
DRAK2
DYRK1A
DYRK1B
DYRK2
DYRK3
DYRK4
EGFR
EphA1
EphA10
EphA2
EphA3
EphA4
EphA5
EphA6
EphA7
EphA8
EphB1
EphB2
EphB3
EphB4
EphB6
HER2
HER3
HER4
ERK1
ERK2
ERK3
ERK4
ERK5
ERK7
FAK
Fer
Fes
FGFR1
FGFR2
FGFR3
FGFR4
Fgr
FLT1
FLT3
FLT4
FmS/CSFR
mTOR/FRAP
FRK
Fused
Fyn
GAK
GCK
GCN2
GCN2~b
GRK4
GRK5
GRK6
GRK7
GSK3α
GSK3β
Haspin
HCK
HGK/ZC1
HH498
HIPK1
HIPK2
HIPK3
HIPK4
HPK1
HRI
HSER
HUNK
ICK
IGF1R
IKKα
IKKβ
IKKε
ILK
InSR
IRAK1
IRAK2
IRAK3
IRAK4
IRE1
IRE2
IRR
ITK
JAK1
JAK1~b
JAK2
JAK2~b
JAK3
JAK3~b
JNK1
JNK2
JNK3
KDR
KHS1
KHS2
KIS
Kit
KSR
KSR2
LATS1
LATS2
Lck
LIMK1
LIMK2
Lkb1
Lmr1
Lmr2
Lmr3
LOK
LRRK1
LRRK2
LTK
Lyn
LZK
MAK
MEK1/MAP2K1
MEK2/MAP2K2
MKK3/MAP2K3
SEK1/MAP2K4
MAP2K5
MKK6/MAP2K6
MAP2K7
MEKK1/MAP3K1
MAP3K8
MEKK2/MAP3K2
MEKK3/MAP3K3
MAP3K4
ASK/MAP3K5
MEKK6/MAP3K6
MAP3K7
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MAST1
MAST2
MAST3
MAST4
MASTL
MELK
Mer
Met
MINK/ZC3
MISR2
MLK1
MLK2
MLK3
MLK4
MLKL
MNK1
MNK2
MOK
MOS
MPSK1
MRCKα
MRCKβ
MSK1
MSK1~b
MSK2
MSK2~b
MSSK1
MST1
MST2
MST3
MST4
MUSK
MYO3A
MYO3B
MYT1
NDR1
NDR2
Nek1
Nek10
Nek11
Nek2
Nek3
Nek4
Nek5
Nek6
Nek7
Nek8
Nek9
NIK
NIM1
NLK
NRBP1
NRBP2
NRK/ZC4
NuaK1
NuaK2
Obscn
Obscn~b
OSR1
P38α
P38β
P38δ
P38γ
p70S6K
p70S6Kβ
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PASK
PBK
PCTAIRE1
PCTAIRE2
PCTAIRE3
PDGFRα
PDGFRβ
PDHK1
PDHK3
PDHK4
PDK1
PERK/PEK
PFTAIRE1
PFTAIRE2
PhKγ1
PhKγ2
PIK3R4
Pim1
Pim2
Pim3
PINK1
PITSLRE
PKAα
PKAβ
PKAγ
PKCα
PKCβ
PKCδ
PKCε
PKCγ
PKCη
PKCι
PKCθ
PKCζ
PKD1
PKD2
PKD3
PKG1
PKG2
PKN1/PRK1
PKN2/PRK2
PKN3
PKR
PLK1
PLK2
PLK3
PLK4
PRKX
PRKY
PRP4
PRPK
PSKH1
PSKH2
PYK2
QIK
QSK
RAF1
Ret
RHODK/GRK1
RIOK1
RIOK2
RIOK3
RIPK1
RIPK2
RIPK3
RNAseL
ROCK1
ROCK2
Ron
ROR1
ROR2
Ros
RSK1/p90RSK
RSK1~b
RSK2
RSK2~b
RSK3
RSK3~b
RSK4
RSK4~b
RSKL1
RSKL2
RYK
SBK
SCYL1
SCYL2
SCYL3
SgK069
SgK071
SgK085
SGK1
SgK110
SgK196
SGK2
SgK223
SgK269
SgK288
SGK3
SgK307
SgK396
SgK424
SgK493
SgK494
SgK495
SgK496
SIK
skMLCK
SLK
Slob
SMG1
smMLCK
SNRK
SPEG
SPEG~b
Src
Srm
SRPK1
SRPK2
SSTK
STK33
STLK3
STLK5
STLK6
SuRTK106
Syk
TAK1
TAO1
TAO2
TAO3
TBCK
TBK1
TEC
TESK1
TESK2
TGFβR1
TGFβR2
TIE1
TIE2
TIFα
TIFβ
TIFγ
TLK1
TLK2
TNIK/ZC2
Tnk1
Trad
Trb1
Trb2
Trb3
Trio
TRKA
TRKB
TRKC
TRRAP
TSSK1
TSSK2
TSSK3
TSSK4
TTBK1
TTBK2
TTK
TTN
TXK
Tyk2
Tyk2~b
Tyro/Sky
ULK1
ULK2
ULK3
ULK4
VACAMKL
VRK1
VRK2
VRK3
Wee1
Wee1B
WNK1
WNK2
WNK3
WNK4
YANK1
YANK2
YANK3
Yes
YSK1
ZAK
ZAP70
EEF2K
ABC1
Alpha
Brd
PDHK
PIKK
RIO
TIF1
Atypical Kinases
STE
CK1
AGC
CAMK
CMGC
TK
TKL
M
+p
+p
-p
+p
+u
S-phase proteins
Growth Factor
DNA damage checkpoint
+p
DNA
Securin
+p
+p
Separin
+p
+p
Condensin
+p
+p
G1
+p
+p
-p
+p
+p
G2
e
e
S
e
+p
+p
+u
+u
+u
+u
p21
p27,57
p16,15,18,19
e
e
+p
R-point
(start)
Growth Factor
withdrawal
DNA
PLK1
CCNA1
CCNA2
CCNB2
CDK1
CCNB3
MD2L1
CDK1
MPEG1
RB
CHK2
TFDP1
BUB1B
RBL1
CHK1
CDC7
PRKDC
DBF4A
P53
CDC45
CDK2
CDC6
HDAC8
CDN1B
HDAC7
PMYT1
HDAC6
SKP2
HDAC5
SKP2
HDAC3
CC14A
HDAC2
CC14B
HDAC1
CADH1
MPIP1
TBCD8
GA45A
MEN1
1433G
ESPL1
PCNA
SMC1A
CCNA2
MDM2
CCNA1
ARF1
CCNE1
E2F1
CDN1A
E2F2
CD2A2
E2F3
CCND2
E2F5
E2F4
RBL1
E2F6
UBE2F
CCNB1
SMAD3
TGFB1
SMAD4
HDAC4
CCNE2
CDC20
SCF
APC
APC
SCF
MCM2
YWHAG
DNA Replication
MAPK Signaling Pathway
Ubiquitin-Mediated Proteolysis
Apoptosis
ATM
ABL1
ATR
MD2L2
BUB1
BUB3
EP300
WEE1
PTTG1
PTTG2
PTTG3
RB
RB
MPIP2
MPIP3
CDK2
CDK2
CDK4
CDK6
CCND3
GSK3B
MD1L1
CCNH
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
MCM3
MCM4
MCM5
MCM6
MCM7
MCM8
MCM9
MCM10
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
Title:
Cell Cycle
Organism:
Homo sapiens
Legend:
IRF5KD_NT
Log2FC:
[-3, 0, 3]
IRF5KD_CpG
Log2FC:
[-3, 0, 3]
Scr_CpG
Log2FC:
[-3, 0, 3]
Mock_CpG
Log2FC:
[-3, 0, 3]
Mgll
Slc5a10
2510009E07Rik
Ecscr
Cenpf
S100a6
Sv2a
Kdm5d
Eif2s3y
Ddx3y
Uty
Stk26
Cables1
Slco4a1
Parn
Fam76b
Hgsnat
Mapre2
Pip5k1c
Zfp697
Cirbp
Rbm3
Lsp1
Anxa11
Card9
Zfpm1
Jpx
Akap5
Erc1
Wdr44
Pid1
Ftx
Cxcl16
Rnf128
Pbdc1
Slamf7
Cxcl14
Il2rg
Itgax
Cd72
Lpl
1810030O07Rik
5530601H04Rik
Chpt1
Flt1
Nes
Il1rn
Lox
Ch25h
Spp1
Igsf8
Ankrd13d
Fgr
St8sia6
Pxdc1
Epb4.1l3
Enpp5
Lppr4
Clec5a
Gal3st4
Ptplad2
E2f1
Gpr34
Tmem29
Sfi1
Emr4
Suv420h2
Trpm2
Nfkb2
Tlr2
Tlr7
C030034L19Rik
Pla2g7
Il1r1
Bhlhe40
Cspg4
Atp1a3
Ccl4
Ccl3
Egr1
Sepw1
Csf1
Ptger4
Fam20c
Cdk18
Fxyd5
Gpx1
Ssx2ip
Mrc2
Eif2s3x
Kdm6a
Kdm5c
Ddx3x
Pou6f1
Rbm5
Gas7
C920009B18Rik
Nedd9
Tm6sf1
Genotype
Gender
WT-6F
WT-1F
Het-2F
WT-3F
WT-5F
WT-7F
Het-7F
WT-8F
Het-8F
Het-6F
KO-1M
KO-8F
KO-9F
KO-7F
KO-4F
WT-2F
Het-3M
Het-5M
Het-1M
WT-9M
Het-4M
WT-4M
WT-10M
KO-3M
KO-2M
KO-12M
KO-6M
KO-10M
KO-11M
Ddx3x
Kdm5c
Kdm6a
Eif2s3x
Csf1
Ccl3
Ccl4
Il1r1
Tlr7
Tlr2
Nfkb2
Il1rn
Itgax
Il2rg
Cxcl14
Cxcl16
Uty
Ddx3y
Eif2s3y
Kdm5d
S100a6
Genotype
WT
Het
KO
Gender
M
F
log2(TPM)
Z-score
-10
-5
0
5
10
Pathways
Sex chromosome genes
Other immune genes
Chemokines and chemokine receptors